Cargolux Airlines International (CV/CLX) began weekly Friday cargo flights from ORD, last week. The flight is operated with a 747-400F, and continues onto SYD. The flight arrives around 1445, and departs around 1600.
The last European cargo company to operate a similar flight was Lufthansa. That MD-11F service lasted a few years, which ended a couple of years ago; it also originated from ORD but continued onto AKL.